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Week 6 -- Discussion 6

Week 6 -- Discussion 6

Q Unit 6: Discussion Pick 2 of the bulleted prompts below to write about in this week’s discussion. Unit 6 – Lymphatic/Immune System • Discuss the structure and function of the lymphatic organs. (USLO 6.1) • Pick 2 of the following defenses of the innate system and describe them. o Physical Barriers o Phagocytes & Macrophages o Immune Surveillance o Interferons o Complement o Inflammation o Fever • Pick 2 of the following defenses of adaptive cellular immunity and describe them. o Cells: Cytotoxic T cells, Helper T cells, Regulatory T cells o Antigen Presentation: Class 1 MHC, Class 2 MHC o Antigen Recognition: CD8 cells, CD4 cells o Co-stimulation o Activation of CD8 cells. o Activation of CD4 cells. • Pick 2 of the following defenses of adaptive humoral immunity and describe them. o B cells o B cell steps ? Sensitization ? Activation o Antibody classes, structure, and functions ? Structure: light chain, heavy chain, variable and constant region. ? Immunoglobulins: IgG, IgM, IgA, IgE, IgD o Primary vs secondary response • Differentiate natural vs artificial immunity. Give examples of each. • Discuss 4 homeostatic imbalances of the immune system and what is occurring physiologically in a person with the condition ________________________________________________________________________ General Discussion Requirements Your initial response to the Prompt below should be posted no later than midnight on Day 4 of the academic week. Your input should be in your own words, demonstrating your understanding and comprehension of the topic. Copying and Pasting from the internet will result in a zero. It is expected that you will include both in-text and final references properly formatted in APA on all initial discussion postings. For help with this refer to the Academic Writer tab to the left of your screen. Then, I want to see you respond to your classmates in the middle of the week (try for Day 4, 5, or 6). The purpose here is to generate discussion to further explore the topics...ask questions, add insight, agree or disagree, etc. Of course, all discussion should be positive and professional. Do not complete all discussions requirements in one sitting; you should post in the discussion 3-4 different days throughout the week. If you have questions about this participation requirement, post them to the Course Questions Forum. Refer to the rubric/syllabus for a complete breakdown of the expectations.

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• Inflammation Cytokines are secreted when innate immune responses are triggered in the initial stages of a viral infection. Cytokines rapidly released at the site of infection generate additional reactions that result in inflammation and the growth of cells that help other cells grow. Tumor necrosis factor alpha (TNF-?) is generated by activated monocytes and macrophages, and is produced one of the first cytokines in the body. this cytokine causes surrounding capillaries to constrict, facilitating the transportation of circulating white blood cells to the infection location It has also been shown to attach to cells infected with the virus, causing an antiviral response (Thomas et al. 2009).